PUBLICATIONS

Below is a list of every paper/ book chapter published with the help of C-SOPS by year. If you require further assistance with locating an article, please contact Doug Hausner.

 
2006  |  2007  |  2008 |  2009  |  2010 |  2011  |  2012 |  2013  |  2014 |  2015  |  2016 |  2017

Journal Papers

  1. Adamo, A., Beingessner, R. L., Behnam, M., Chen, J., Jamison, T. F., Jensen, K. F., ... & Stelzer, T. (2016). On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system. Science, 352(6281), 61-67.

  2. Adepu, M., Hate, S., Bétard, A., Oka, S., Schongut, M., Sen, M., ... & Muzzio, F. (2016). Quantitative validation and analysis of the regime map approach for the wet granulation of industrially relevant zirconium hydroxide powders. Powder Technology, 294, 177-184.

  3. Alcala M., Martinez L., Esquerdo R., Hausner D., Romañach R. J., (2015) Continuous Manufacturing, Near Infrared Spectroscopy and Process Knowledge, American Pharmaceutical Review, 18 (5), 59-63, D1.

  4. Azad M, Moreno J, Bilgili E, Davé RN. (2016) Fast dissolution of poorly water soluble drugs from fluidized bed coated nanocomposites: Impact of carrier size. International Journal of Pharmaceutics.513(1–2):319-31.

  5. Banquet-Terán, J., Johnson-Restrepo, B., Hernández-Morelo, A., Ropero, J., Fontalvo-Gomez, M., & Romañach, R. J. (2016). Linear and Nonlinear Calibration Methods for Predicting Mechanical Properties of Polypropylene Pellets Using Raman Spectroscopy. Applied spectroscopy, 70(7), 1118-1127.

  6. Besenhard, M. O., Karkala, S. K., Faulhammer, E., Fathollahi, S., Ramachandran, R., & Khinast, J. G. (2016). Continuous feeding of low-dose APIs via periodic micro dosing. International journal of pharmaceutics, 509(1), 123-134.

  7. Bilgili, E., Li, M., & Afolabi, A. (2016). Is the combination of cellulosic polymers and anionic surfactants a good strategy for ensuring physical stability of BCS Class II drug nanosuspensions?. Pharmaceutical development and technology, 21(4), 499-510.

  8. Cárdenas V, Roman-Ospino A. Romañach RJ. Recent Advances in Obtaining Process Information from Near Infrared Spectra. American Pharmaceutical Review 2016;19 (7), 22-25.

  9. Cui, Y., O’Mahony, M., Jaramillo, J. J., Stelzer, T., & Myerson, A. S. (2016). Custom-Built Miniature Continuous Crystallization System with Pressure-Driven Suspension Transfer. Organic Process Research & Development, 20(7), 1276-1282.

  10. Deng, X., Huang, Z., Wang, W., & Davé, R. N. (2016). Investigation of nanoparticle agglomerates properties using Monte Carlo simulations. Advanced Powder Technology, 27(5), 1971-1979.

  11. Emady, H. N., Anderson, K. V., Borghard, W. G., Muzzio, F. J., Glasser, B. J., & Cuitino, A. (2016). Prediction of conductive heating time scales of particles in a rotary drum. Chemical Engineering Science, 152, 45-54.

  12. Esbensen, K. H., Román-Ospino, A. D., Sanchez, A., & Romañach, R. J. (2016). Adequacy and verifiability of pharmaceutical mixtures and dose units by variographic analysis (Theory of Sampling)–A call for a regulatory paradigm shift. International journal of pharmaceutics, 499(1), 156-174.

  13. Grigorov, P. I., Glasser, B. J., & Muzzio, F. J. (2016). Improving dissolution kinetics of pharmaceuticals by fluidized bed impregnation of active pharmaceutical ingredients. AIChE Journal, 62(12), 4201-4214.

  14. Hernandez, E., Pawar, P., Keyvan, G., Wang, Y., Velez, N., Callegari, G., ... & Romañach, R. J. (2016). Prediction of dissolution profiles by non-destructive near infrared spectroscopy in tablets subjected to different levels of strain. Journal of pharmaceutical and biomedical analysis, 117, 568-576.

  15. Hernández, E., Pawar, P., Rodriguez, S., Lysenko, S., Muzzio, F. J., & Romañach, R. J. (2016). Effect of shear applied during a pharmaceutical process on near infrared spectra. Applied spectroscopy, 70(3), 455-466.

  16. Içten, E., Joglekar, G. S., Giridhar, A., & Reklaitis, G. V. (2016). Application of a Knowledge Management System to a Dropwise Additive Manufacturing System for Pharmaceuticals. Computer Aided Chemical Engineering, 38, 619-24.

  17. Içten, E., Joglekar, G., Wallace, C., Loehr, K., Sacksteder, J., Giridhar, A., ... & Reklaitis, G. V. (2016). Knowledge Provenance Management System for a Dropwise Additive Manufacturing System for Pharmaceutical Products. Industrial & Engineering Chemistry Research, 55(36), 9676-9686.

  18. Ierapetritou, M., Muzzio, F., & Reklaitis, G. (2016). Perspectives on the continuous manufacturing of powder‐based pharmaceutical processes. AIChE Journal, 62(6), 1846-1862.

  19. Koynov, S., Muzzio, F. J., & Glasser, B. J. (2016). A novel consolidation method to measure powder flow properties using a small amount of material. AIChE Journal, 62(12), 4193-4200.

  20. Koynov, S., Wang, Y., Redere, A., Amin, P., Emady, H. N., Muzzio, F. J., & Glasser, B. J. (2016). Measurement of the axial dispersion coefficient of powders in a rotating cylinder: dependence on bulk flow properties. Powder Technology, 292, 298-306.

  21. Krull, S. M., Ma, Z., Li, M., Davé, R. N., & Bilgili, E. (2016). Preparation and characterization of fast dissolving pullulan films containing BCS class II drug nanoparticles for bioavailability enhancement. Drug development and industrial pharmacy, 42(7), 1073-1085.

  22. Krull, S. M., Patel, H. V., Li, M., Bilgili, E., & Davé, R. N. (2016). Critical material attributes (CMAs) of strip films loaded with poorly water-soluble drug nanoparticles: I. Impact of plasticizer on film properties and dissolution. European Journal of Pharmaceutical Sciences, 92, 146-155.

  23. Laínez-Aguirre, J. M., Mockus, L., Orçun, S., Blau, G., & Reklaitis, G. V. (2016). A decomposition strategy for the variational inference of complex systems. Technometrics, 58(1), 84-94.

  24. Li, M., Azad, M., Davé, R., & Bilgili, E. (2016). Nanomilling of drugs for bioavailability enhancement: a holistic formulation-process perspective. Pharmaceutics, 8(2), 17.

  25. Li, M., Lopez, N., & Bilgili, E. (2016). A study of the impact of polymer–surfactant in drug nanoparticle coated pharmatose composites on dissolution performance. Advanced Powder Technology, 27(4), 1625-1636.

  26. Li, M., Zhang, L., Davé, R. N., & Bilgili, E. (2016). An intensified vibratory milling process for enhancing the breakage kinetics during the preparation of drug nanosuspensions. AAPS PharmSciTech, 17(2), 389-399.

  27. Liu, Y., & Wassgren, C. (2016). Modifications to Johanson's roll compaction model for improved relative density predictions. Powder Technology, 297, 294-302.

  28. Mateo-Ortiz, D., & Méndez, R. (2016). Microdynamic analysis of particle flow in a confined space using DEM: The feed frame case. Advanced Powder Technology, 27(4), 1597-1606.

  29. Meng, W., Kotamarthy, L., Panikar, S., Sen, M., Pradhan, S., Marc, M., ... & Ramachandran, R. (2016). Statistical analysis and comparison of a continuous high shear granulator with a twin screw granulator: effect of process parameters on critical granule attributes and granulation mechanisms. International journal of pharmaceutics, 513(1), 357-375.

  30. Monbaliu, J. C. M., Stelzer, T., Revalor, E., Weeranoppanant, N., Jensen, K. F., & Myerson, A. S. (2016). Compact and Integrated Approach for Advanced End-to-End Production, Purification, and Aqueous Formulation of Lidocaine Hydrochloride. Organic Process Research & Development, 20(7), 1347-1353.

  31. Muzzio FJ, Panikar S. Analyzing the microstructure of blend samples., Powder and Bulk Engineering. September 2016.

  32. Oka S, Moghtadernejad S, Liu Z, Hausner D, Muzzio FJ. (2016) Lubrication in Continuous Tubular Powder Blenders. Pharm Technol. 40 (11): 44-45.

  33. Osorio, J. G., Hernández, E., Romañach, R. J., & Muzzio, F. J. (2016). Characterization of resonant acoustic mixing using near-infrared chemical imaging. Powder Technology, 297, 349-356.

  34. Osorio, J. G., Stuessy, G., Kemeny, G. J., & Muzzio, F. J. (2016). Micro-mixing dynamics of active pharmaceutical ingredients in bin-blending. Chemical Engineering and Processing: Process Intensification, 102, 141-155.

  35. Palma, F., Michniak-Kohn, B., Pérez-Correa, J. R., Hernandez, E., Romañach, R. J., & Valenzuela, L. M. (2016). Near-infrared chemical imaging and its correlation with the mechanical properties of chitosan–gelatin edible films. Carbohydrate polymers, 136, 409-417.

  36. Panikar S, Muzzio FJ. (2016) Advances in 3D Raman Imaging: Tablet Microstructure., Am. Pharmaceut. Rev. 19, 6.

  37. Pawar, P., Joo, H., Callegari, G., Drazer, G., Cuitino, A. M., & Muzzio, F. J. (2016). The effect of mechanical strain on properties of lubricated tablets compacted at different pressures. Powder Technology, 301, 657-664.

  38. Pawar, P., Joo, H., Callegari, G., Drazer, G., Cuitino, A. M., & Muzzio, F. J. (2016). The effect of mechanical strain on properties of lubricated tablets compacted at different pressures. Powder Technology, 301, 657-664.

  39. Pawar, P., Wang, Y., Keyvan, G., Callegari, G., Cuitino, A., & Muzzio, F. (2016). Enabling real time release testing by NIR prediction of dissolution of tablets made by continuous direct compression (CDC). International journal of pharmaceutics, 512(1), 96-107.

  40. Razavi, S. M., Callegari, G., Drazer, G., & Cuitiño, A. M. (2016). Toward predicting tensile strength of pharmaceutical tablets by ultrasound measurement in continuous manufacturing. International journal of pharmaceutics, 507(1), 83-89.

  41. Romañach R, Near infrared spectroscopy: from feasibility to implementation in the pharmaceutical industry. NIR news 2016, 27 (1), 33-38.

  42. Romañach, R. J., & Esbensen, K. H. (2016). Theory of sampling (TOS) for development of spectroscopic calibration models. American Pharmaceutical Review, 19(6).

  43. Romañach, RJ, (2016) Independence and Dependence in Calibration: A Discussion of FDA and EMA Guidelines. American Pharmaceutical Review, 19 (4), 46-49.

  44. Román-Ospino, A. D., Singh, R., Ierapetritou, M., Ramachandran, R., Méndez, R., Ortega-Zuñiga, C., ... & Romañach, R. J. (2016). Near infrared spectroscopic calibration models for real time monitoring of powder density. International journal of pharmaceutics, 512(1), 61-74.

  45. Sánchez-Paternina, A., Román-Ospino, A. D., Martínez, M., Mercado, J., Alonso, C., & Romañach, R. J. (2016). Near infrared spectroscopic transmittance measurements for pharmaceutical powder mixtures. Journal of pharmaceutical and biomedical analysis, 123, 120-127.

  46. Scicolone, J. V., Metzger, M., Koynov, S., Anderson, K., Takhistov, P., Glasser, B. J., & Muzzio, F. J. (2016). Effect of liquid addition on the bulk and flow properties of fine and coarse glass beads. AIChE Journal, 62(3), 648-658.

  47. Singh R, Muzzio FJ, Ierapetritou M, Ramachandran R. (2016) Systematic framework for design and implementation of plant-wide multilayer, sensing and control architecture into continuous pharmaceutical manufacturing plant. Computer Aided Chemical Engineering. 2016, accepted.

  48. Stelzer, T., Wong, S. Y., Chen, J., & Myerson, A. S. (2016). Evaluation of PAT Methods for Potential Application in Small-Scale, Multipurpose Pharmaceutical Manufacturing Platforms. Organic Process Research & Development, 20(8), 1431-1438.

  49. Wang Y, Snee RD, Keyvan G, Muzzio FJ. (2016) Statistical comparison of dissolution  profiles. Drug development and industrial pharmacy. 42.5: 796-807.

  50. Wang, Y., Koynov, S., Glasser, B. J., & Muzzio, F. J. (2016). A method to analyze shear cell data of powders measured under different initial consolidation stresses. Powder Technology, 294, 105-112.

  51. Wang, Y., Snee, R. D., Meng, W., & Muzzio, F. J. (2016). Predicting flow behavior of pharmaceutical blends using shear cell methodology: a quality by design approach. Powder Technology, 294, 22-29.

  52. Wu, S., Panikar, S. S., Singh, R., Zhang, J., Glasser, B., & Ramachandran, R. (2016). A systematic framework to monitor mulling processes using Near Infrared spectroscopy. Advanced Powder Technology, 27(4), 1115-1127.

Conference Papers & Invited Talks

  1. Azad M, Moreno J, Bilgili E, Davé RN. Core-Shell Nanocomposites for Fast Release of Hydrophobic Active Pharmaceutical Ingredients: Impact of Carrier Size. AIChE Annual Meeting, San Francisco, CA. Nov. 2016, Paper No: 766c.

  2. Azad M, Sievens-Figueroa L, Bilgili E, Davé RN. Physicochemical Properties of Biocompatible Films Containing Concentrated Fenofibrate Particles Prepared Via Liquid Antisolvent Precipitation. AIChE Annual Meeting, San Francisco, CA. Nov. 2016, Paper No: 197g

  3. Bilgili E, Li M, Alvarez P, Orbe P. Elucidating the Physical Stability of Griseofulvin Nanosuspensions Via Combined Use of Surface Charge, Stabilizer Adsorption, and Wettability Measurements. AIChE Annual Meeting, San Francisco, CA. Nov. 2016, Paper No: 726e.

  4. Bilgili E, Li M, Ioannidis N, Suriel I, Gogos CG. Nanoextrusion: A Platform Enabling Comparative Assessment of Nanocomposites Vs. Amorphous Solid Dispersions for Drug Dissolution Enhancement. AIChE Annual Meeting, San Francisco, CA. Nov. 2016, Paper No: 384d.

  5. Bilgili E, Li M, Zhang L, Armani M, Orbe P, Aloia M, Pielecha-Safira B, Davé RN. Particle Engineering Research from the NSF ERC Research Experience for Teachers (RET) Program at NJIT. AIChE Annual Meeting, San Francisco, CA.  Nov. 2016, Paper No: 44d.

  6. Krull SM, Li M, Bilgili E, Davé RN. Maximizing Poorly Water-Soluble API Nanoparticle Loading in Polymer Strip Films. AIChE Annual Meeting, San Francisco, CA. Nov. 2016, Paper No: 44a.

  7. Krull SM, Li M, Bilgili E, Davé RN. Modeling Dissolution of Polymer Strip Films Loaded with Poorly Water-Soluble Drug Nanoparticles. AIChE Annual Meeting, San Francisco, CA. Nov. 2016, Paper No: 766g.

  8. Moreno, M., Q.Su, Z. Nagy, G.V. Reklaitis, “Real Time Monitoring and Modeling of Milling in a Continuous Tableting Line via Dry Granulation”, paper 742g, AICHE 2016 Annual Meeting. San Francisco, Nov 13-18, 2016

  9. Nirupaplava Metta, Marianthi Ierapetritou and Rohit Ramachandran, “A Combined Experimental and Computational Approach Using Discrete Element Method for the Development of a Mechanistically Motivated Breakage Kernel”. 2016 AIChE Annual Meeting, San Francisco, CA, November 15, 2016.

  10. Purohit, S. H., Taylor, S. L. (2016). Interplay of amorphous-amorphous phase separation and liquid-liquid phase separation in governing the dissolution performance of ritonavir amorphous solid dispersions. Presented as a poster at AAPS annual meeting, Orlando, USA, November 2016. Poster # 23M0330.

  11. Purohit, S. H., Taylor, S. L. (2016). Interplay of amorphous-amorphous phase separation and liquid-liquid phase separation in governing the dissolution performance of ritonavir amorphous solid dispersions. Presented as a poster at Arden conference on amorphous pharmaceuticals, Baltimore, USA, April 2016. 

  12. Ravendra Singh, Fernando J. Muzzio, Rohit Ramachandran and Marianthi Ierapetritou, “Advanced Flexible Control System Implementation into Direct Compaction Continuous Pharmaceutical Manufacturing Pilot-Plant”. 2016 AIChE Annual Meeting, San Francisco, CA, November 17, 2016.

  13. Ravendra Singh, Glinka Cathy Pereira, Nikita Soni, Andrés D. Román-Ospino, Marianthi Ierapetritou and Rohit Ramachandran, “Feedforward Control of Continuous Pharmaceutical Manufacturing Process”. 2016 AIChE Annual Meeting, San Francisco, CA, November 18, 2016.

  14. Reklaitis, G.V.  “Advances in Pharmaceutical Manufacturing”, India/Purdue Collaborative Lecture / C.N.R. Rao Lecture, Indian Institute of Science, Bangalore, India, Feb 2, 2016

  15. Reklaitis, G.V.  “Advances in Pharmaceutical Manufacturing”, India/Purdue Collaborative Lecture/C.N.R. Rao Lecture, Dr Reddy’s Laboratories, Hyderabad, India, Feb 4, 2016

  16. Reklaitis, G.V.  “Process Systems Engineering: Current Impact and Future Directions”, Procesa 2016, Bogota, Colombia, April 27, 2016, plenary lecture

  17. Reklaitis, G.V.  “Recent Advances in Continuous Pharmaceutical Manufacturing”, Clemson University, Dept of Chemical and Biomolecular Engineering, March 24, 2016

  18. Reklaitis, G.V.  “Recent Advances in Continuous Pharmaceutical Manufacturing”, Institute of Chemical Technology, Mumbai, India, Feb 1, 2016

  19. Su, Q., M. Moreno, S. Ganesh, A. Giridhar, G.V. Reklaitis, Z. Nagy, “Fault-Tolerant Control Design and Risk MAP-based Resiliency Analysis of Continuous Solid Oral Dose Manufacture”, paper 233n, AICHE 2016 Annual Meeting. San Francisco, Nov 13-18, 2016

  20. Voronov R, Basuray S, Obuskovic G, Simon L, Barat RB, Bilgili E. Statistical Analysis of Undergraduate ChE Curricula of U.S. Universities. AIChE Annual Meeting, San Francisco, CA. Nov. 2016, Paper No: 610b.

  21. Zilong Wang, M. Sebastian Escotet-Espinoza, Ravendra Singh, Fernando J. Muzzio and Marianthi G. Ierapetritou. "Feasibility Analysis of Flowsheet Models in Continuous Pharmaceutical Manufacturing Processes Considering the Effects of Noise". 2016 AIChE Annual Meeting, San Francisco, CA, November 14, 2016.

  22. Zilong Wang, M. Sebastian Escotet-Espinoza, Ravendra Singh, Fernando J. Muzzio and Marianthi G. Ierapetritou. "Surrogate-Based Optimization Methodology for Pharmaceutical Tablet Manufacturing Processes". 2016 AIChE Annual Meeting, San Francisco, CA, November 17, 2016.

Publications from Associated Projects

  1. Oka S, Muzzio FJ. Using Residence Time Distributions to Understand Continuous Powder Blenders. Powder and Bulk Engineering. May 2017.

  2. Oka S, Moghtadernejad S, Liu Z, Hausner D, Muzzio FJ. Lubrication in Continuous Tubular Powder Blenders. Pharm Technol. 2016;40 (11): 44-45.

  3.  Oka S, Escotet-Espinoza MS, Singh R, Scicolone J, Hausner D, Ierapetritou M, Muzzio FJ. 3. Design of an integrated continuous manufacturing system. F. A chapter of book Continuous manufacturing of pharmaceuticals edited by Peter Kleinebudde, Johannes Khinast and Jukka Rantanen. Publisher: Wiley-VCH. 2016, Accepted.

  4.  Panikar S, Muzzio FJ. Advances in 3D Raman Imaging: Tablet Microstructure., Am. Pharmaceut. Rev. 2016;19, 6.

  5. Muzzio FJ, Panikar S. Analyzing the microstructure of blend samples., Powder and Bulk Engineering. September 2016.

  6. Pawar P, Muzzio FJ. Approaches for dissolution prediction of Tablets made by continuous manufacturing direct compaction- Towards Real Time Release testing.

  7. Singh R, Muzzio FJ, Ierapetritou M, Ramachandran R. Plant-wide control of a continuous tablet manufacturing for Quality-by-Design based pharmaceutical manufacturing. Computer Aided Chemical Engineering. 2015;37: 2183 - 2188. http://dx.doi.org/10.1016/B978-0-444-63576-1.50058-3

  8. Karry KM., Singh R, Muzzio FJ. Fit-for-Purpose Miniature NIR Spectroscopy for Solid Dosage Continuous Manufacturing. American Pharmaceutical Review. 2015;18(4): 64 - 67.

  9. Escotet-Espinoza MS, Singh R, Sen M, O’Connor T, Lee S, Chatterjee S, Ramachandran R, Ierapetritou M, Muzzio FJ. Flowsheet Models Modernize Pharmaceutical Manufacturing Design and Risk Assessment, Pharmaceutical Techno. 2015;39 (4): 34-42.

  10. Cárdenas V, Roman-Ospino A. Romañach RJ. Recent Advances in Obtaining Process Information from Near Infrared Spectra. American Pharmaceutical Review 2016;19 (7), 22-25.

  11. Romañach RJ, Esbensen, KH, Theory of Sampling (TOS) - for Development of Spectroscopic Calibration Models American Pharmaceutical Review 2016, 19 (6), 138-139.

  12. Romañach, RJ, Independence and Dependence in Calibration: A Discussion of FDA and EMA Guidelines. American Pharmaceutical Review 2016, 19 (4), 46-49.