C-SOPS

Journal Papers

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1. Alcala M., Martinez L., Esquerdo R., Hausner D., Romañach R. J., “Continuous Manufacturing, Near Infrared Spectroscopy and Process Knowledge”, American Pharmaceutical Review 2015, 18 (5), 59-63, D1.

2. Azad M., Afolabi A., Bhakay A., Leonardi J., Davé R., Bilgili E., “Enhanced Physical Stabilization of Fenofibrate Nanosuspensions via Wet Co-Milling with a Superdisintegrant and an Adsorbing Polymer”, European Journal of Pharmaceutics and Biopharmaceutics, Vol. 94, pp 372-385, August 2015, DOI:10.1016/j.ejpb.2015.05.028, A1.

3. Azad M., Arteaga C., Abdelmalek B., Davé R., Bilgili E., “Spray Drying of Drug–Swellable Dispersant Suspensions for Preparation of Fast-Dissolving, High Drug-Loaded, Surfactant-Free Nanocomposites”, Drug Development and Industrial Pharmacy, Vol. 41, pp 1617-1631, 2015, DOI:10.3109/03639045.2014.976574, A8

4. Barrasso D., and * Ramachandran R., “Qualitative assessment of a multi-scale, compartmental PBM-DEM model of a continuous twin-screw wet granulation process”, Journal of Pharmaceutical Innovation, 1-19, 2015. 

5. Barrasso D., Eppinger T., Perera F., Aglave R., Debus K., Bermingham S., * Ramachandran R., “A multi-scale, mechanistic model of a wet granulation process using a novel bi-directional PBM-DEM coupling algorithm”, Chemical Engineering Science, 123, 500-513 2015. 

6. Barrasso D., Tamrakar A., * Ramachandran R., “Model order reduction of a multi-scale PBM-DEM description of a wet granulation (published)

7. Bhakay A., Vizzotti E., Li M., Davé R., Bilgili E., “Incorporation of Colloidal Fenofibrate Particles Prepared by Melt Emulsification into Polymeric Strip Films”, Journal of Pharmaceutical Innovation, Vol. 11, pp 53-63, March 2016, DOI:10.1007/s12247-015-9237-2, A8.

8. Bilgili E., Li M., Afolabi A., “Is the Combination of Cellulosic Polymers and Anionic Surfactants a Good Strategy for Ensuring Physical Stability of BCS Class II Drug Nanosuspensions?”, Pharmaceutical Development and Technology, Vol. 21, pp 499-510, 2016, DOI:10.3109/10837450.2015.1022788, A1.

9. Capece M., Dave R. N., Bilgili E., “On the Origin of Non-linear Breakage Kinetics in Dry Milling”, Powder Technology, Vol. 272, pp 189–203, March 2015, DOI:10.1016/j.powtec.2014.11.040, A1.

10. Deng X., Scicolone J., Han X., Davé R. N., “Discrete Element Method Simulation of a Conical Screen Mill: A Continuous Dry Coating Device”, Chemical Engineering Science, Vol. 125, pp 58–74, March 2015, DOI: 10.1016/j.ces.2014.08.051, A6 (also C2).

11. Emady H.N., Wittman M., Koynov S., Borghard W.G., Muzzio F.J., Glasser B.J., Cuitino A.M., “A simple color concentration measurement technique for powders”, Powder Technology 286, pp. 392, 2015. 

12. Engisch W., and Muzzio F., “Using Residence Time Distributions (RTD) To Address The Traceability Of Raw Materials In Continuous Pharmaceutical Manufacturing”, Journal of Pharmaceutical Innovation, 11 64-81 (2016) DOI: 10.1007/s12247-015-9238-1.

13. Engisch W., and Muzzio F.J., “Feedrate Deviations Caused by Hopper Refill of Loss-in-Weight Feeders”, Powder Technology, Powder Technology 283, pp. 389, 2015. 

14. Engisch W.E., Muzzio F.J., “Loss-in-Weight Feeding Trials Case Study: Pharmaceutical Formulation”, Journal of Pharmaceutical Innovation, 10, 56-75 (2015) 

15. Escotet-Espinoza M. S., Singh R., Sen M., O’Connor T., Lee S., Chatterjee S., Ramachandran R., Ierapetritou M., Muzzio F., “Flowsheet Models Modernize Pharmaceutical Manufacturing Design and Risk Assessment”, Pharmaceutical Technology 39 (4), 34-42, D5.

16. Hernandez E., Pawar P., Rodriguez S., Lysenko S., Muzzio F., Romanach R., “The effect of Shear applied during pharmaceutical process on near infrared spectra”, Appied Spectroscopy 70 455-466 (2016). 

17. Hernandez E., Pawar P., Wang Y., Velez N., Keyvan G., Michniak B., Muzzio F., Cuitiño A., and Romañach R.J.,  “Prediction of Dissolution Profiles by Non-Destructive Near Infrared Spectroscopy in Tablets Subjected to Different Levels of Strain. Journal of Pharmaceutical Innovation 117, 568-576 (2016)

18. Huang Z., Scicolone J. V., Gurumurthy L., Davé R. N., “Flow and Bulk Density Enhancements of Pharmaceutical Powders using a Conical Screen Mill: A Continuous Dry Coating Device”, Chemical Engineering Science, Vol. 125, pp 209–224, March 2015, DOI: 10.1016/j.ces.2014.05.038, A6 (also C2).

19. Huang Z., Scicolone J. V., Han X., Davé R. N., “Improved blend and tablet properties of fine pharmaceutical powders via dry particle coating”, International Journal of Pharmaceutics, Vol. 478 (2), pp 447-455, January 2015, DOI:10.1016/j.ijpharm.2014.11.068, A6 (also C2).

20. Ierapetritou M., Muzzio F., and Reklaitis G., “Perspectives in the continuous manufacturing of powder-based pharmaceutical processes”, AIChE J. 62, 1846–1862 (2016)

21. Jallo L. J. and Davé R. N., “Explaining Electrostatic Charging and Flow of Surface-Modified Acetaminophen Powders as a Function of Relative Humidity Through Surface Energetics”, Journal of Pharmaceutical Sciences, Vol. 104, pp 2225–2232, June 2015. , DOI: 10.1002/jps.24479, A6,

22. Karry K.M., Singh R., Muzzio F.J., “Fit-for-purpose miniature NIR spectroscopy for solid dosage continuous manufacturing”, American Pharmaceutical Review 18 (4), 2015.

23. Knieke C., Azad M., To D., Bilgili E., Davé R., “Sub-100 Micron Fast Dissolving Nanocomposite Drug Powders”, Powder Technology, Vol. 271, pp 49–60, February 2015, DOI:10.1016/j.powtec.2014.10.024, A8.

24. Koynov S., Glasser B., Muzzio F., “Comparison of three rotational shear cell testers: Powder flowability and bulk density”, Powder Technology 283, pp. 103, 2015. 

25. Koynov S., Muzzio F.J., “A quantitative approach to understand raw material variability”, Methods in Pharmacology and Toxicology 32, pp. 85, 2015.

26. Koynov S., Wang Y., Muzzio F.; Glasser B., "Measurement of the Axial Dispersion Coefficient of Powders in a Rotating Cylinder: Dependence on Bulk Flow Properties", Powder Technology 292 298–306 (2016)

27. Krull S. M., Li M., Bilgili E., Davé R. N., “Polymer Strip Films for Delivery of Poorly Water-Soluble Drugs”, American Pharmaceutical Review, Vol. 18, pp 48-52, 2015, A8.

28. Krull S., Ma Z., Li M., Dave R. N., Bilgili E., “Preparation and Characterization of Fast Dissolving Pullulan Films Containing Griseofulvin Nanoparticles for Bioavailability Enhancement”, Drug Development and Industrial Pharmacy, pp 1-13, November 2015, DOI:10.3109/03639045.2015.1107094, A8.

29. Krull S., Susarla R., Afolabi A., Li M., Ying Y., Iqbal Z., Bilgili E., Davé R. N., “Polymer Strip Films as a Robust, Surfactant-Free Platform for Delivery of BCS Class II Drug Nanoparticles”, International Journal of Pharmaceutics,Vol. 489, pp 45–57, July 2015, DOI:10.1016/j.ijpharm.2015.04.034, A8.

30. Li M., Yaragudi N., Afolabi A., Dave R., Bilgili E., “Sub-100 nm drug particle suspensions prepared via wet milling with low bead contamination through novel process intensification”, Chemical Engineering Science, Vol.130, pp 207–220, July 2015, DOI:10.1016/j.ces.2015.03.020, A1.

31. Li M., Zhang L., Dave R., Bilgili E.,“An Intensified Vibratory Milling Process for Enhancing the Breakage Kinetics During the Preparation of Drug Nanosuspensions”, AAPS PharmSciTech, pp 1-11, July 2015, DOI:10.1208/s12249-015-0364-3, A1.

32. Liu Y., Wassgren C., “Modifications to Johanson’s roll compaction model for improved relative density predictions”, Powder Technology, Vol 297, pp. 294 - 302, 2016, Compaction/B4.

33. Moreno M., Giridhar A., Reklaitis G.V., Nagy Z., “Nonlinear Steady-State Data Reconciliation for A Continuous Tableting Line” (incomplete)

34. Oka S., Emady H., Kaspar O., Tokarova V., Muzzio F., Stepanek F., * Ramachandran R., “The effects of improper mixing and preferential mixing of active and excipient ingredients on content uniformity in high shear wet granulation”, Powder Technology, 278, 266-277, 2015. 

35. Oka S., Kašpar O., Tokárová V., Sowrirajan K., Wu H., Khan M., Muzzio F., Štěpánek F., Ramachandran R., “A quantitative study of the effect of process parameters on key granule characteristics in a high shear wet granulation process involving a two component pharmaceutical blend”, Advanced Powder Technology, Vol.26, No.1, 315-322, 2015. 

36. Osorio J. G., and Muzzio F. J., “Characterization of Resonant Acoustic Mixing using Near-Infrared Chemical Imaging”, Powder Technology 297, 349–356 (2016)

37. Osorio J.G., and Muzzio F.J., “Evaluation of Resonant Acoustic Mixing Performance”, Powder Technology, 278, pp. 46, 2015. 

38. Osorio J. , Stuessy G. , Kemeny G. , and Muzzio F.J., "Micro-mixing dynamics of active pharmaceutical ingredients in bin-blending", Chemical Engineering and Processing: Process Intensification, 102, 141-155 (2016). 

39. Razavi S., Gonzalez M., Cuitino A.M., “General and mechanistic optimal relationships for tensile strength of doubly convex tablets under diametrical compression”, International Journal of Pharmaceutics, DOI: 10.1016/j.ijpharm.2015.02.030, 

40. Rogers A., Ierapetritou M., “Challenges and Opportunities in Modeling Pharmaceutical Manufacturing Processes”, Computers and Chemical Engineering, 81, 32-39, 2015, D5.

41. Rogers A., Ierapetritou M., “Feasibility and flexibility analysis of black-box processes Part 2: Surrogate-based flexibility analysis”, Chemical Engineering Science, 137, 1005-1013, 2015, D5.

42. Rogers A., Ierapetritou M., “Feasibility and flexibility analysis of black-box processes Part 1: Surrogate-based feasibility analysis”, Chemical Engineering Science, 137, 986-1004, 2015, D5.

43. Roman-Ospino A., Ortega-Zuñiga C., Sanchez-Paternina A., Ortiz S., Esbensen K., Romañach R., “Estimating total sampling error for near infrared spectroscopic analysis of pharmaceutical blends—theory of sampling to the rescue”, TOS Forum, 2015; pp 71-75, D1.

44. Scicolone J., Glasser B., and Muzzio F., “Effect of Liquid Addition on the Bulk and Flow Properties of Fine and Coarse Glass Beads”, AIChE Journal 62, 648–658 (2016).

45. Singh R., Ierapetritou M., Ramachandran R., “The scopes of PAT in real-time advanced control of tablet quality”, European Pharmaceutical Review 20(2), 76-80, D2.

46. Singh R., Muzzio F., Ierapetritou M., Ramachandran R., “A combined feed-forward/feed-back control system for a QbD based continuous tablet manufacturing process”, PROCESSES Journal, 3, 339-356, D2.

47. Singh R., Muzzio F., Ierapetritou M., Ramachandran R., “Plant-wide control of a continuous tablet manufacturing for Quality-by-Design based pharmaceutical manufacturing”, Computer Aided Chemical Engineering, 37, 2183 – 2188, D2

48. Singh R., Román-Ospino A. D., Romañach R. J., Ierapetritou M., Ramachandran R., “Real time monitoring of powder blend bulk density for coupled feed-forward/feed-back control of a continuous direct compaction tablet manufacturing process”, International Journal of Pharmaceutics 2015, 495 (1), 612-625, D2.

49. Singh R., Sen M., Ierapetritou M., Ramachandran R., “Integrated moving horizon based dynamic real time optimization and hybrid MPC-PID control of a direct compaction continuous tablet manufacturing process”, Journal of Pharmaceutical Innovation, 10 (3), 233-253, D2.

50. Singh R., Velazquez C., Sahay A., Karry K.M., Muzzio F.J., Ierapetritou M.G., Ramachandran R., “Advanced control of continuous pharmaceutical tablet manufacturing processes”, Methods in Pharmacology and Toxicology 32, pp. 191, 2015.

51. Singh R., Zhang J., Ierapetritou M., Ramachandran R., “Designing a novel continuous manufacturing plant with superior monitoring and control”, European Pharmaceutical Review, 20(6), 37-41. D2.

52. Susarla R., Afolabi A., Patel D., Bilgili E., Dave R., “Novel Use of Superdisintegrants as Viscosity Enhancing Agents in Biocompatible Polymer Films Containing Griseofulvin Nanoparticles”, Powder Technology, Vol. 285, pp 25–33, November 2015, DOI:10.1016/j.powtec.2015.06.024, A8.

53. Taylor L. S., Prohit H.S., “Miscibility of Itraconazole-Hydroxypropyl Methylcellulose Blends- Insights with High Resolution Analytical Methodologies,” Molecular Pharmaceutics, 12(12):4542-4542, 2015.

54. Taylor L. S., Prohit H.S., “Phase Separation Kinetics in Amorphous Solid Dispersions Upon Exposure to Water”, Molecular Pharmaceutics, 12(5):1623-1635, (2015).

55. Taylor L. S., Schram C. J., Beaudoin S. P., “Influence of Polymers on the Crystal Growth Rate of Felodipine – Correlating Adsorbed Polymer Surface Coverage to Solution Crystal Growth Inhibition, Langmuir, 31(41):11279-11287.

56. Taylor L. S., Trasi N. S., “Thermodynamics of Highly Supersaturated Aqueous Solutions of Poorly Water Soluble Drugs – Impact of a Second Drug on the Solution Phase Behavior and Implications for Combination Products”, Journal of Pharmaceutical Sciences, 104(8):2583-2593.

57. Wang Y., Glasser B., and Muzzio F., “A Method to Analyze Shear Cell Data of Powders Measured under Different Initial Consolidation Stresses”, Powder Technology 294, 105-112 (2016).

58. Wang Y. , Meng W., Snee R.D., Muzzio F.J., "Predicting Flow Behavior of Pharmaceutical Blends Using Shear Cell Methodology: A Quality by Design Approach", Powder Technology 294 (2016)

59. Wang Y., Snee R.D., Keyvan G., Muzzio F.J., “Statistical Comparison of Dissolution Profiles”, Drug Dev. and Ind. Pharmacy, dx.doi.org/10.3109/03639045.2015.1078349. 

60. Yohannes B., Gonzalez M., Abebe A., Sprockel O., Nikfar F., Kiang S., Cuitino A.M., “Evolution of the microstructure during the process of consolidation and bonding in soft granular solids”, International Journal of Pharmaceutics, DOI:10.1016/j.ijpharm.2016.02.032