Webinar Series: Powder Handling and Characterization for Design of Pharmaceutical Manufacturing Proc
While powder handling and processing is common in pharmaceutical manufacturing, multiple challenges, for example jamming of hoppers, sub-standard blending performance, weight variability of final products, and process scale-up failures, are encountered during production due to lack of fundamental understanding of powder behavior. Powder characterization techniques have a central role in both product and process development. By characterizing materials using a substantial numb
Webinar Series Registration: Powder Handling and Characterization for Design of Pharmaceutical Manuf
C-SOPS Webinar Series Presents Powder Handling and Characterization for Design of Pharmaceutical Manufacturing Processes Yifan Wang, Ph.D. Wednesday October 12 2016 @ 1:30PM EST While powder handling and processing is common in pharmaceutical manufacturing, multiple challenges, for example jamming of hoppers, sub-standard blending performance, weight variability of final products, and process scale-up failures, are encountered during production due to lack of fundamental unde
Webinar Series: New Methods for Extracting Information from Continuous Manufacturing Processes Throu
New Near Infrared Spectroscopy (NIRS) spectroscopic methods were developed for real time determination of powder density and to estimate the total sampling error (TSE) in continuous blending processes. Powder density is a critical property in the manufacturing of solid oral dosages that affects tablet mass, hardness and dissolution. The establishment of calibration techniques for powder density resulted in the new strategies to control the amount of active pharmaceutical ingr
Webinar Series Registration: New Methods for Extracting Information from Continuous Manufacturing Pr
C-SOPS Webinar Series Presents New Methods for Extracting Information from Continuous Manufacturing Processes Through Real Time Spectroscopic Analysis Andres D. Román-Ospino, Ph.D. Now Tuesday September 13 2016 @ 1:30PM EST New Near Infrared Spectroscopy (NIRS) spectroscopic methods were developed for real time determination of powder density and to estimate the total sampling error (TSE) in continuous blending processes. Powder density is a critical property in the manufactu
Webinar Series: Enabling real time release testing by NIR prediction of dissolution of tablets by Co
The methodology enables real-time release testing. Tablets were made at a target drug concentration of 9% APAP, containing 90% lactose and 1% Magnesium Stearate, and at a target compression force of 24 kN. A model for predicting dissolution profiles was developed using a fractional factorial experimental design built around this targeted condition. This experimental design consisted of a 3^(4-1) fractional design resulting into a total of 27 testing conditions with additional
