Common challenges in PAT and continuous manufacturing include connecting data and models to real-time processes, and subsequently assure quality and channel results to desired locations. Most organizations will have multiple data sources that require alignment, which is a natural starting point when planning an end-to-end solution that can bridge R&D efforts with manufacturing that is happening in real time. Ultimately some of the main goals are to reduce time to market and
C-SOPS Webinar Series Presents New Methods for Extracting Information from Continuous Manufacturing Processes Through Real Time Spectroscopic Analysis Andres D. Román-Ospino, Ph.D. Now Tuesday September 13 2016 @ 1:30PM EST New Near Infrared Spectroscopy (NIRS) spectroscopic methods were developed for real time determination of powder density and to estimate the total sampling error (TSE) in continuous blending processes. Powder density is a critical property in the manufactu
The methodology enables real-time release testing. Tablets were made at a target drug concentration of 9% APAP, containing 90% lactose and 1% Magnesium Stearate, and at a target compression force of 24 kN. A model for predicting dissolution profiles was developed using a fractional factorial experimental design built around this targeted condition. This experimental design consisted of a 3^(4-1) fractional design resulting into a total of 27 testing conditions with additional
C-SOPS Webinar Series Presents Enabling real time release testing by NIR
prediction of dissolution of tablets by
Continuous Direct Compression (CDC) Pallavi Pawar, Ph.D.
Wednesday July 27th 2016 @ 1PM EST The methodology enables real-time release testing. Tablets were made at a target drug concentration of 9% APAP, containing 90% lactose and 1% Magnesium Stearate, and at a target compression force of 24 kN. A model for predicting dissolution profiles was developed using a
An introduction to continuous manufacturing operations with an emphasis on direct compression of pharmaceutical products. These two 5-day courses will provide background seminars and hands-on training in the CpAML manufacturing facility located on the Rutgers University Piscataway campus. These trainings will include four integral aspects of Continuous Manufacturing (Continuous Direct Compaction- CDC) divided over a two-week period. Unit operations of direction compression Pr